CHMP6

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
CHMP6 VPS20,FLJ11749, VPS20 charged multivesicular body protein 6 NM_024591 pdf

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Description

This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein family. Proteins in this family are part of the ESCRT-III (endosomal sorting complex required for transport III) which degrades surface receptors, and in biosynthesis of endosomes. Gene is lowly expressed in human. It is transiently upregulated in MARV and wt 7h, and stably expressed in EBOV. The bat homolog is upregulated in MARV.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome20 31 12 24 30 31 22 40 23
Read_Max
batR. aegyptiacusTranscriptome 83 92 57 59 64 88 59 80 131
Read_Max
bat_genomeR. aegyptiacusGenome 76 57 46 87 45 52 48 82 128
DESeq
humanH. sapiensGenome 112.63 179.48 93.33 164.12 134.32 154.96 144.86 204.04 156.49
DESeq
batR. aegyptiacusTranscriptome 231.2 256.97 242.86 174.06 229.87 257.64 235.72 232.34 322.89
DESeq
bat_genomeR. aegyptiacusGenome 561.18 540.31 584.67 653.71 570.34 633.12 565.64 630.39 741.46

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 112.63 164.12 144.86 0.54 0.36 -0.18
7h 179.48 134.32 204.04 -0.42 0.19 0.6
23h 93.33 154.96 156.49 0.73 0.75 0.01

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 112.63 179.48 93.33 0.67 -0.27 -0.94
Ebov 164.12 134.32 154.96 -0.29 -0.08 0.21
Marv 144.86 204.04 156.49 0.49 0.11 -0.38

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 231.2 174.06 235.72 -0.41 0.03 0.44
7h 256.97 229.87 232.34 -0.16 -0.15 0.02
23h 242.86 257.64 322.89 0.09 0.41 0.33

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 231.2 256.97 242.86 0.15 0.07 -0.08
Ebov 174.06 229.87 257.64 0.4 0.57 0.16
Marv 235.72 232.34 322.89 -0.02 0.45 0.47