DDIT4

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
DDIT4 REDD1,RTP801, FLJ20500, REDD-1, REDD1, Dig2 DNA-damage-inducible transcript 4 NM_019058 pdf

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Description

Homo sapiens DNA-damage-inducible transcript 4.

REDD1 (regulated in development and DNA damage responses 1, DDIT4) was identified as a \update activator that upon increased expression is able to suppress AKT1 signaling as well as mTor signaling pathways [Gu et al., Blood, 2014, 123:3269-3276; Ellisen, Cell Cycle, 2005, 4:1500-1502]. Vesicular stomatitis virus and influenza virus were shown to be inhibited by chemical inhibitors inducing REDD1 expression and the resulting mTORC1 inhibition. Reduction of viral replication was rescued by using REDD1 deficient cells [Mata \emph, 2011, 7:712-719].

The human transcript is upregulated in later time points in mock infected and Marburg virus infected data but not in Ebola.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome39 77 118 67 72 70 38 82 110
Read_Max
batR. aegyptiacusTranscriptome 45 9 103 51 54 68 12 56 117
Read_Max
bat_genomeR. aegyptiacusGenome 44 51 90 11 35 42 11 55 121
DESeq
humanH. sapiensGenome 302.39 446.68 763.49 372.86 370.89 337.88 208.9 347.12 740.4
DESeq
batR. aegyptiacusTranscriptome 173.23 48.2 599.55 236.33 201.4 320.51 44.38 179.46 389.37
DESeq
bat_genomeR. aegyptiacusGenome 183.05 251.9 615.91 64.19 191.98 366.82 37.11 176.83 415.25

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 302.39 372.86 208.9 0.3 -0.53 -0.84
7h 446.68 370.89 347.12 -0.27 -0.36 -0.1
23h 763.49 337.88 740.4 -1.18 -0.04 1.13

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 302.39 446.68 763.49 0.56 1.34 0.77
Ebov 372.86 370.89 337.88 -0.01 -0.14 -0.13
Marv 208.9 347.12 740.4 0.73 1.83 1.09

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 173.23 236.33 44.38 0.45 -1.96 -2.41
7h 48.2 201.4 179.46 2.06 1.9 -0.17
23h 599.55 320.51 389.37 -0.9 -0.62 0.28

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 173.23 48.2 599.55 -1.85 1.79 3.64
Ebov 236.33 201.4 320.51 -0.23 0.44 0.67
Marv 44.38 179.46 389.37 2.02 3.13 1.12