DDIT4

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
DDIT4	REDD1,RTP801, FLJ20500, REDD-1, REDD1, Dig2	DNA-damage-inducible transcript 4	NM_019058	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Homo sapiens DNA-damage-inducible transcript 4.

REDD1 (regulated in development and DNA damage responses 1, DDIT4) was identified as a \update activator that upon increased expression is able to suppress AKT1 signaling as well as mTor signaling pathways [Gu et al., Blood, 2014, 123:3269-3276; Ellisen, Cell Cycle, 2005, 4:1500-1502]. Vesicular stomatitis virus and influenza virus were shown to be inhibited by chemical inhibitors inducing REDD1 expression and the resulting mTORC1 inhibition. Reduction of viral replication was rescued by using REDD1 deficient cells [Mata \emph, 2011, 7:712-719].

The human transcript is upregulated in later time points in mock infected and Marburg virus infected data but not in Ebola.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	39	77	118	67	72	70	38	82	110
Read_Max	R. aegyptiacus	Transcriptome	45	9	103	51	54	68	12	56	117
Read_Max	R. aegyptiacus	Genome	44	51	90	11	35	42	11	55	121
DESeq	H. sapiens	Genome	302.39	446.68	763.49	372.86	370.89	337.88	208.9	347.12	740.4
DESeq	R. aegyptiacus	Transcriptome	173.23	48.2	599.55	236.33	201.4	320.51	44.38	179.46	389.37
DESeq	R. aegyptiacus	Genome	183.05	251.9	615.91	64.19	191.98	366.82	37.11	176.83	415.25

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	302.39	372.86	208.9	0.3	-0.53	-0.84
7h	446.68	370.89	347.12	-0.27	-0.36	-0.1
23h	763.49	337.88	740.4	-1.18	-0.04	1.13

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	302.39	446.68	763.49	0.56	1.34	0.77
Ebov	372.86	370.89	337.88	-0.01	-0.14	-0.13
Marv	208.9	347.12	740.4	0.73	1.83	1.09

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	173.23	236.33	44.38	0.45	-1.96	-2.41
7h	48.2	201.4	179.46	2.06	1.9	-0.17
23h	599.55	320.51	389.37	-0.9	-0.62	0.28

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	173.23	48.2	599.55	-1.85	1.79	3.64
Ebov	236.33	201.4	320.51	-0.23	0.44	0.67
Marv	44.38	179.46	389.37	2.02	3.13	1.12

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material