ACTR3

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
ACTR3 Arp3,ARP3 ARP3 actin-related protein 3 homolog (yeast) NM_005721 pdf

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Description

The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. The gene is uniformely expressed in human, but shows an additional splice site in EBOV 3h (10\% of the alternative splice sites). It is highly but uniformly expressed in bat.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome766 788 781 820 1074 1188 1020 1148 960
Read_Max
batR. aegyptiacusTranscriptome 2136 1871 1202 1770 1587 1836 1748 2135 2023
Read_Max
bat_genomeR. aegyptiacusGenome 2164 1799 982 1714 1302 1046 1442 2496 2085
DESeq
humanH. sapiensGenome 6827.47 6115.14 6372.95 7344.72 6896.45 8376.84 7186.18 6629.21 8810.68
DESeq
batR. aegyptiacusTranscriptome 10940.47 10142.62 7837.16 9414.07 9832.72 11046.63 11496.6 9857.67 9102.34
DESeq
bat_genomeR. aegyptiacusGenome 15394.25 13557.93 10228.33 15196.38 14597.91 15984.74 17433.62 13848.01 12751.26

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 6827.47 7344.72 7186.18 0.11 0.07 -0.03
7h 6115.14 6896.45 6629.21 0.17 0.12 -0.06
23h 6372.95 8376.84 8810.68 0.39 0.47 0.07

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 6827.47 6115.14 6372.95 -0.16 -0.1 0.06
Ebov 7344.72 6896.45 8376.84 -0.09 0.19 0.28
Marv 7186.18 6629.21 8810.68 -0.12 0.29 0.41

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 10940.47 9414.07 11496.6 -0.22 0.07 0.29
7h 10142.62 9832.72 9857.67 -0.04 -0.04 0.0
23h 7837.16 11046.63 9102.34 0.5 0.22 -0.28

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 10940.47 10142.62 7837.16 -0.11 -0.48 -0.37
Ebov 9414.07 9832.72 11046.63 0.06 0.23 0.17
Marv 11496.6 9857.67 9102.34 -0.22 -0.34 -0.12