EPS15

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
EPS15 AF-1P, AF1P, MLLT5 epidermal growth factor receptor pathway substrate 15 NM_001981 pdf

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Description

This gene encodes a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias.Uniformly expressed in human. Highly expressed in bat, with a slight increase in MARV 23h compared to 3h.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome212 162 170 160 217 239 202 230 200
Read_Max
batR. aegyptiacusTranscriptome 380 311 236 324 280 354 306 409 451
Read_Max
bat_genomeR. aegyptiacusGenome 467 367 234 392 251 241 284 556 526
DESeq
humanH. sapiensGenome 4110.89 3303.35 3568.22 3285.03 3227.6 4094.83 3083.5 3086.49 4561.33
DESeq
batR. aegyptiacusTranscriptome 4978.83 4561.23 4062.61 4828.4 4852.25 5332.62 5264.91 5224.29 5306.11
DESeq
bat_genomeR. aegyptiacusGenome 6079.33 5717.06 4609.28 5908.11 5677.77 6478.75 6459.31 6009.74 6239.07

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 4110.89 3285.03 3083.5 -0.32 -0.41 -0.09
7h 3303.35 3227.6 3086.49 -0.03 -0.1 -0.06
23h 3568.22 4094.83 4561.33 0.2 0.35 0.16

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 4110.89 3303.35 3568.22 -0.32 -0.2 0.11
Ebov 3285.03 3227.6 4094.83 -0.03 0.32 0.34
Marv 3083.5 3086.49 4561.33 0.0 0.56 0.56

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 4978.83 4828.4 5264.91 -0.04 0.08 0.12
7h 4561.23 4852.25 5224.29 0.09 0.2 0.11
23h 4062.61 5332.62 5306.11 0.39 0.39 -0.01

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 4978.83 4561.23 4062.61 -0.13 -0.29 -0.17
Ebov 4828.4 4852.25 5332.62 0.01 0.14 0.14
Marv 5264.91 5224.29 5306.11 -0.01 0.01 0.02