IRS1

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
IRS1	HIRS-1	insulin receptor substrate 1	NM_005544	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The insulin receptor substrate 1 is involved in the cGMP-PKG, FoxO, mTOR, PI3K-Akt, AMPK, Neurotrophin, Insulin and Adipocytokine signaling pathways. It is also related to Type II diabetes mellitus, Non-alcoholic fatty liver disease (NAFLD), Aldosterone-regulated sodium reabsorption and MicroRNAs in cancer. It seems to be slightly downregulated after 23 hours of Marburg infection in humans.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	177	179	124	166	207	260	221	215	107
Read_Max	R. aegyptiacus	Transcriptome	179	148	80	149	127	142	148	130	115
Read_Max	R. aegyptiacus	Genome	218	145	69	146	111	100	135	159	135
DESeq	H. sapiens	Genome	6134.37	5163.6	4477.65	5470.58	4913.66	6314.79	5251.07	4809.09	3911.1
DESeq	R. aegyptiacus	Transcriptome	2763.38	2375.52	1724.59	2262.7	2340.11	2460.86	2592.91	1922.76	1588.6
DESeq	R. aegyptiacus	Genome	4721.49	3783.99	2949.0	4244.2	4230.15	4138.15	4900.71	3514.34	2725.26

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	6134.37	5470.58	5251.07	-0.17	-0.22	-0.06
7h	5163.6	4913.66	4809.09	-0.07	-0.1	-0.03
23h	4477.65	6314.79	3911.1	0.5	-0.2	-0.69

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	6134.37	5163.6	4477.65	-0.25	-0.45	-0.21
Ebov	5470.58	4913.66	6314.79	-0.15	0.21	0.36
Marv	5251.07	4809.09	3911.1	-0.13	-0.43	-0.3

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	2763.38	2262.7	2592.91	-0.29	-0.09	0.2
7h	2375.52	2340.11	1922.76	-0.02	-0.31	-0.28
23h	1724.59	2460.86	1588.6	0.51	-0.12	-0.63

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	2763.38	2375.52	1724.59	-0.22	-0.68	-0.46
Ebov	2262.7	2340.11	2460.86	0.05	0.12	0.07
Marv	2592.91	1922.76	1588.6	-0.43	-0.71	-0.28

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material