IRS1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
IRS1 HIRS-1 insulin receptor substrate 1 NM_005544 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The insulin receptor substrate 1 is involved in the cGMP-PKG, FoxO, mTOR, PI3K-Akt, AMPK, Neurotrophin, Insulin and Adipocytokine signaling pathways. It is also related to Type II diabetes mellitus, Non-alcoholic fatty liver disease (NAFLD), Aldosterone-regulated sodium reabsorption and MicroRNAs in cancer. It seems to be slightly downregulated after 23 hours of Marburg infection in humans.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome177 179 124 166 207 260 221 215 107
Read_Max
batR. aegyptiacusTranscriptome 179 148 80 149 127 142 148 130 115
Read_Max
bat_genomeR. aegyptiacusGenome 218 145 69 146 111 100 135 159 135
DESeq
humanH. sapiensGenome 6134.37 5163.6 4477.65 5470.58 4913.66 6314.79 5251.07 4809.09 3911.1
DESeq
batR. aegyptiacusTranscriptome 2763.38 2375.52 1724.59 2262.7 2340.11 2460.86 2592.91 1922.76 1588.6
DESeq
bat_genomeR. aegyptiacusGenome 4721.49 3783.99 2949.0 4244.2 4230.15 4138.15 4900.71 3514.34 2725.26

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 6134.37 5470.58 5251.07 -0.17 -0.22 -0.06
7h 5163.6 4913.66 4809.09 -0.07 -0.1 -0.03
23h 4477.65 6314.79 3911.1 0.5 -0.2 -0.69

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 6134.37 5163.6 4477.65 -0.25 -0.45 -0.21
Ebov 5470.58 4913.66 6314.79 -0.15 0.21 0.36
Marv 5251.07 4809.09 3911.1 -0.13 -0.43 -0.3

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 2763.38 2262.7 2592.91 -0.29 -0.09 0.2
7h 2375.52 2340.11 1922.76 -0.02 -0.31 -0.28
23h 1724.59 2460.86 1588.6 0.51 -0.12 -0.63

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 2763.38 2375.52 1724.59 -0.22 -0.68 -0.46
Ebov 2262.7 2340.11 2460.86 0.05 0.12 0.07
Marv 2592.91 1922.76 1588.6 -0.43 -0.71 -0.28