GAB1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
GAB1 GRB2-associated binding protein 1 NM_002039 pdf

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Description

The GRB2-associated binding protein 1 gene is involved in the ErbB, Neurotrophin and Ras signaling pathways, Bacterial invasion of epithelial cells, proteoglycans in cancer and Renal cell carcinoma. It seems to be slightly downregulated after 23 hours of Marburg virus infection in human, and slightly upregulated after 23 hours of Ebola infection in Bat.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome128 138 98 156 110 158 145 160 78
Read_Max
batR. aegyptiacusTranscriptome 162 109 104 146 127 247 116 156 197
Read_Max
bat_genomeR. aegyptiacusGenome 185 159 110 118 111 152 107 198 221
DESeq
humanH. sapiensGenome 2167.57 2105.0 2000.55 2020.01 1900.05 1989.36 1833.48 1435.03 1554.82
DESeq
batR. aegyptiacusTranscriptome 1770.34 1460.57 1664.73 1779.23 1603.12 2729.04 1632.9 1569.14 1875.5
DESeq
bat_genomeR. aegyptiacusGenome 2650.36 2558.26 2690.14 2302.81 2425.36 4075.49 2446.98 2335.23 3008.66

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 2167.57 2020.01 1833.48 -0.1 -0.24 -0.14
7h 2105.0 1900.05 1435.03 -0.15 -0.55 -0.4
23h 2000.55 1989.36 1554.82 -0.01 -0.36 -0.36

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 2167.57 2105.0 2000.55 -0.04 -0.12 -0.07
Ebov 2020.01 1900.05 1989.36 -0.09 -0.02 0.07
Marv 1833.48 1435.03 1554.82 -0.35 -0.24 0.12

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1770.34 1779.23 1632.9 0.01 -0.12 -0.12
7h 1460.57 1603.12 1569.14 0.13 0.1 -0.03
23h 1664.73 2729.04 1875.5 0.71 0.17 -0.54

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1770.34 1460.57 1664.73 -0.28 -0.09 0.19
Ebov 1779.23 1603.12 2729.04 -0.15 0.62 0.77
Marv 1632.9 1569.14 1875.5 -0.06 0.2 0.26