GAB1

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
GAB1		GRB2-associated binding protein 1	NM_002039	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The GRB2-associated binding protein 1 gene is involved in the ErbB, Neurotrophin and Ras signaling pathways, Bacterial invasion of epithelial cells, proteoglycans in cancer and Renal cell carcinoma. It seems to be slightly downregulated after 23 hours of Marburg virus infection in human, and slightly upregulated after 23 hours of Ebola infection in Bat.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	128	138	98	156	110	158	145	160	78
Read_Max	R. aegyptiacus	Transcriptome	162	109	104	146	127	247	116	156	197
Read_Max	R. aegyptiacus	Genome	185	159	110	118	111	152	107	198	221
DESeq	H. sapiens	Genome	2167.57	2105.0	2000.55	2020.01	1900.05	1989.36	1833.48	1435.03	1554.82
DESeq	R. aegyptiacus	Transcriptome	1770.34	1460.57	1664.73	1779.23	1603.12	2729.04	1632.9	1569.14	1875.5
DESeq	R. aegyptiacus	Genome	2650.36	2558.26	2690.14	2302.81	2425.36	4075.49	2446.98	2335.23	3008.66

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	2167.57	2020.01	1833.48	-0.1	-0.24	-0.14
7h	2105.0	1900.05	1435.03	-0.15	-0.55	-0.4
23h	2000.55	1989.36	1554.82	-0.01	-0.36	-0.36

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	2167.57	2105.0	2000.55	-0.04	-0.12	-0.07
Ebov	2020.01	1900.05	1989.36	-0.09	-0.02	0.07
Marv	1833.48	1435.03	1554.82	-0.35	-0.24	0.12

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1770.34	1779.23	1632.9	0.01	-0.12	-0.12
7h	1460.57	1603.12	1569.14	0.13	0.1	-0.03
23h	1664.73	2729.04	1875.5	0.71	0.17	-0.54

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1770.34	1460.57	1664.73	-0.28	-0.09	0.19
Ebov	1779.23	1603.12	2729.04	-0.15	0.62	0.77
Marv	1632.9	1569.14	1875.5	-0.06	0.2	0.26

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material