MCL1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
MCL1 TM, EAT, MCL1L, MCL1S, Mcl-1, BCL2L3,BCL2L3, Mcl-1 myeloid cell leukemia 1 NM_021960 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing.

This gene was found to be with high expression in human and moderate expression in bats, however, without significantly differential expressional level.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome795 890 729 812 1042 1771 1117 1218 970
Read_Max
batR. aegyptiacusTranscriptome 596 497 491 480 388 543 364 512 563
Read_Max
bat_genomeR. aegyptiacusGenome 641 550 510 460 391 329 323 731 666
DESeq
humanH. sapiensGenome 10039.27 9410.35 9049.6 10134.83 9145.88 16369.76 10912.55 10363.78 12249.96
DESeq
batR. aegyptiacusTranscriptome 2191.25 2484.44 3661.95 2603.33 2682.88 3096.03 2233.6 2613.47 2814.06
DESeq
bat_genomeR. aegyptiacusGenome 5431.35 6295.7 7725.65 5923.91 6424.47 7619.68 5775.6 6477.58 6436.85

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 10039.27 10134.83 10912.55 0.01 0.12 0.11
7h 9410.35 9145.88 10363.78 -0.04 0.14 0.18
23h 9049.6 16369.76 12249.96 0.86 0.44 -0.42

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 10039.27 9410.35 9049.6 -0.09 -0.15 -0.06
Ebov 10134.83 9145.88 16369.76 -0.15 0.69 0.84
Marv 10912.55 10363.78 12249.96 -0.07 0.17 0.24

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 2191.25 2603.33 2233.6 0.25 0.03 -0.22
7h 2484.44 2682.88 2613.47 0.11 0.07 -0.04
23h 3661.95 3096.03 2814.06 -0.24 -0.38 -0.14

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 2191.25 2484.44 3661.95 0.18 0.74 0.56
Ebov 2603.33 2682.88 3096.03 0.04 0.25 0.21
Marv 2233.6 2613.47 2814.06 0.23 0.33 0.11