MCL1

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
MCL1	TM, EAT, MCL1L, MCL1S, Mcl-1, BCL2L3,BCL2L3, Mcl-1	myeloid cell leukemia 1	NM_021960	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing.

This gene was found to be with high expression in human and moderate expression in bats, however, without significantly differential expressional level.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	795	890	729	812	1042	1771	1117	1218	970
Read_Max	R. aegyptiacus	Transcriptome	596	497	491	480	388	543	364	512	563
Read_Max	R. aegyptiacus	Genome	641	550	510	460	391	329	323	731	666
DESeq	H. sapiens	Genome	10039.27	9410.35	9049.6	10134.83	9145.88	16369.76	10912.55	10363.78	12249.96
DESeq	R. aegyptiacus	Transcriptome	2191.25	2484.44	3661.95	2603.33	2682.88	3096.03	2233.6	2613.47	2814.06
DESeq	R. aegyptiacus	Genome	5431.35	6295.7	7725.65	5923.91	6424.47	7619.68	5775.6	6477.58	6436.85

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	10039.27	10134.83	10912.55	0.01	0.12	0.11
7h	9410.35	9145.88	10363.78	-0.04	0.14	0.18
23h	9049.6	16369.76	12249.96	0.86	0.44	-0.42

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	10039.27	9410.35	9049.6	-0.09	-0.15	-0.06
Ebov	10134.83	9145.88	16369.76	-0.15	0.69	0.84
Marv	10912.55	10363.78	12249.96	-0.07	0.17	0.24

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	2191.25	2603.33	2233.6	0.25	0.03	-0.22
7h	2484.44	2682.88	2613.47	0.11	0.07	-0.04
23h	3661.95	3096.03	2814.06	-0.24	-0.38	-0.14

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	2191.25	2484.44	3661.95	0.18	0.74	0.56
Ebov	2603.33	2682.88	3096.03	0.04	0.25	0.21
Marv	2233.6	2613.47	2814.06	0.23	0.33	0.11

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material