BAK1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
BAK1 BAK, CDN1, BCL2L7, BAK-LIKE,BCL2L7, BAK BCL2-antagonist/killer 1 NM_001188 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.

This gene was found to be with low expression level in human probes, no homolog was found in bat probes.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome58 66 48 50 65 115 75 98 59
Read_Max
batR. aegyptiacusTranscriptome 240 217 208 178 202 305 197 205 383
Read_Max
bat_genomeR. aegyptiacusGenome 277 201 179 223 185 184 165 274 418
DESeq
humanH. sapiensGenome 453.59 428.33 413.02 410.51 370.08 574.74 401.88 454.23 558.81
DESeq
batR. aegyptiacusTranscriptome 769.73 753.47 846.3 698.74 776.32 1023.7 804.16 693.36 1042.78
DESeq
bat_genomeR. aegyptiacusGenome 1816.75 1584.42 1774.09 2036.19 1750.1 2512.91 2028.66 1635.05 2350.25

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 453.59 410.51 401.88 -0.14 -0.17 -0.03
7h 428.33 370.08 454.23 -0.21 0.08 0.3
23h 413.02 574.74 558.81 0.48 0.44 -0.04

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 453.59 428.33 413.02 -0.08 -0.14 -0.05
Ebov 410.51 370.08 574.74 -0.15 0.49 0.64
Marv 401.88 454.23 558.81 0.18 0.48 0.3

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 769.73 698.74 804.16 -0.14 0.06 0.2
7h 753.47 776.32 693.36 0.04 -0.12 -0.16
23h 846.3 1023.7 1042.78 0.27 0.3 0.03

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 769.73 753.47 846.3 -0.03 0.14 0.17
Ebov 698.74 776.32 1023.7 0.15 0.55 0.4
Marv 804.16 693.36 1042.78 -0.21 0.37 0.59