ANAPC10

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
ANAPC10 APC10, DOC1, DKFZP564L0562 anaphase promoting complex subunit 10 NM_014885 pdf

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Description

ANAPC10 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein ligase that is essential for progression through the cell cycle. APC initiates sister chromatid separation by ubiquitinating the anaphase inhibitor securin (PTTG1; MIM 604147) and triggers exit from mitosis by ubiquitinating cyclin B (CCNB1; MIM 123836), the activating subunit of cyclin-dependent kinase-1 (CDK1; MIM 116940). The gene shows a slight down regulation in both, EBOV and MARV infected human cell samples 23h p.i..

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome32 29 31 32 30 31 38 49 23
Read_Max
batR. aegyptiacusTranscriptome 52 43 58 29 35 37 29 45 48
Read_Max
bat_genomeR. aegyptiacusGenome 63 38 42 48 34 21 31 62 57
DESeq
humanH. sapiensGenome 352.12 276.37 261.12 322.67 267.65 211.55 307.14 230.41 252.18
DESeq
batR. aegyptiacusTranscriptome 153.07 107.2 141.48 95.31 108.32 103.65 92.22 116.67 91.97
DESeq
bat_genomeR. aegyptiacusGenome 495.01 434.44 384.94 368.33 371.67 270.22 475.68 428.98 342.48

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 352.12 322.67 307.14 -0.13 -0.2 -0.07
7h 276.37 267.65 230.41 -0.05 -0.26 -0.22
23h 261.12 211.55 252.18 -0.3 -0.05 0.25

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 352.12 276.37 261.12 -0.35 -0.43 -0.08
Ebov 322.67 267.65 211.55 -0.27 -0.61 -0.34
Marv 307.14 230.41 252.18 -0.41 -0.28 0.13

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 153.07 95.31 92.22 -0.68 -0.73 -0.05
7h 107.2 108.32 116.67 0.01 0.12 0.11
23h 141.48 103.65 91.97 -0.45 -0.62 -0.17

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 153.07 107.2 141.48 -0.51 -0.11 0.4
Ebov 95.31 108.32 103.65 0.18 0.12 -0.06
Marv 92.22 116.67 91.97 0.34 -0.0 -0.34