AP2M1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
AP2M1 AP50, CLAPM1, mu2 adaptor-related protein complex 2, mu 1 subunit NM_004068 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a subunit of the heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. The encoded protein is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. The encoded protein may also play an important role in regulating the intracellular trafficking and function of CTLA-4 protein. Two transcript variants encoding different isoforms have been found for this gene.

The gene AP2M1 is expressed throughout human cells and bat cells datasets with significant upregulation in bat cells 23 h after Marburg infection.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome320 680 491 553 605 630 604 990 474
Read_Max
batR. aegyptiacusTranscriptome 365 325 320 290 227 308 224 333 519
Read_Max
bat_genomeR. aegyptiacusGenome 405 321 325 324 231 190 201 502 623
DESeq
humanH. sapiensGenome 2959.1 4799.5 3184.99 4536.36 3711.31 4226.43 4507.2 5382.23 3429.4
DESeq
batR. aegyptiacusTranscriptome 2312.23 2506.22 3352.9 2239.81 2302.88 2829.13 2186.88 2406.92 3442.98
DESeq
bat_genomeR. aegyptiacusGenome 2846.3 2721.63 3772.44 3237.96 2834.98 3392.76 2687.63 2805.44 3961.6

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 2959.1 4536.36 4507.2 0.62 0.61 -0.01
7h 4799.5 3711.31 5382.23 -0.37 0.17 0.54
23h 3184.99 4226.43 3429.4 0.41 0.11 -0.3

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 2959.1 4799.5 3184.99 0.7 0.11 -0.59
Ebov 4536.36 3711.31 4226.43 -0.29 -0.1 0.19
Marv 4507.2 5382.23 3429.4 0.26 -0.39 -0.65

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 2312.23 2239.81 2186.88 -0.05 -0.08 -0.03
7h 2506.22 2302.88 2406.92 -0.12 -0.06 0.06
23h 3352.9 2829.13 3442.98 -0.25 0.04 0.28

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 2312.23 2506.22 3352.9 0.12 0.54 0.42
Ebov 2239.81 2302.88 2829.13 0.04 0.34 0.3
Marv 2186.88 2406.92 3442.98 0.14 0.65 0.52