Supplement Table 2: Amount of identified differentially expressed genes within each of the four investigated tissues and between the four different ages. For every tissue we performed six pairwise age comparisons (9, 15, 24 and 30 months against each other). Besides the DEG names and log2 foldchanges you can find the results of the DESeq2 and edgeR analysis for every age comparision, as well as the overlap between both tools.
Supplement Figure 2A:Venn diagram of all differentially expressed genes (DEGs) in the four analyzed tissues. Whereas most DEGs are unique for the single tissues, a total of 125 genes are still common in at least three tissues and seven in all of them. The total amount of DEGs in the individual tissues is written in brackets. The different sets of DEGs can be downloaded on the right hand-side of the venn diagram.
Supplement Figure 2B: Expression plots of the seven genes being differentially expressed in all four investigated tissues during aging.
Gene Name
Blood Expression
Brain Expression
Liver Expression
Skin Expression
Gm8979
Igkv4-62
Lcn2
Rap2a
S100a6
S100a9
Vmp1
Supplement Figure 2C: Temporal expression profiles of the seven genes gm8979, igkv4-62, lcn2, rap2a, s100a6, s100a9 and vmp1, being differentially expressed in all four tissues during aging. The y-axis provide the expression strength as normalized counts of expressed reads of each gene. Note that the positions of the figure legends indicate which boxplots belong to which y-scale, for each gene respectively. With exception to lcn2 and s100a9 and gm8979, none of the genes show a consistent expression pattern that is shared between the tissues.