Differentially Expressed Genes During Aging

Supplement Data 2:
Detailed gene expression profils for Blood DEGs
Detailed gene expression profils for Brain DEGs
Detailed gene expression profils for Liver DEGs
Detailed gene expression profils for Skin DEGs

Supplement Table 2: Amount of identified differentially expressed genes within each of the four investigated tissues and between the four different ages. For every tissue we performed six pairwise age comparisons (9, 15, 24 and 30 months against each other). Besides the DEG names and log2 foldchanges you can find the results of the DESeq2 and edgeR analysis for every age comparision, as well as the overlap between both tools.
Tissue 9m vs 15m 9m vs 24m 9m vs 30m 15m vs 24m 15m vs 30m 24m vs 30m
blood DESeq2 results
edgeR results

results overlap
MA-Plot
DESeq2 results
edgeR results

results overlap
MA-Plot
DESeq2 results
edgeR results

results overlap
MA-Plot
DESeq2 results
edgeR results

results overlap
MA-Plot
DESeq2 results
edgeR results

results overlap
MA-Plot
DESeq2 results
edgeR results

results overlap
MA-Plot
brain DESeq2 results
edgeR results

results overlap
MA-Plot
DESeq2 results
edgeR results

results overlap
MA-Plot
DESeq2 results
edgeR results

results overlap
MA-Plot
DESeq2 results
edgeR results

results overlap
MA-Plot
DESeq2 results
edgeR results

results overlap
MA-Plot
DESeq2 results
edgeR results

results overlap
MA-Plot
liver DESeq2 results
edgeR results

results overlap
MA-Plot
DESeq2 results
edgeR results

results overlap
MA-Plot
DESeq2 results
edgeR results

results overlap
MA-Plot
DESeq2 results
edgeR results

results overlap
MA-Plot
DESeq2 results
edgeR results

results overlap
MA-Plot
DESeq2 results
edgeR results

results overlap
MA-Plot
skin DESeq2 results
edgeR results

results overlap
MA-Plot
DESeq2 results
edgeR results

results overlap
MA-Plot
DESeq2 results
edgeR results

results overlap
MA-Plot
DESeq2 results
edgeR results

results overlap
MA-Plot
DESeq2 results
edgeR results

results overlap
MA-Plot
DESeq2 results
edgeR results

results overlap
MA-Plot


Overlapping DEGs During Aging


Supplement Figure 2A:Venn diagram of all differentially expressed genes (DEGs) in the four analyzed tissues. Whereas most DEGs are unique for the single tissues, a total of 125 genes are still common in at least three tissues and seven in all of them. The total amount of DEGs in the individual tissues is written in brackets. The different sets of DEGs can be downloaded on the right hand-side of the venn diagram.
Venn Gene Sets
S1: Gene List
S2: Gene List
S3: Gene List
S4: Gene List
S5: Gene List
S6: Gene List
S7: Gene List
S8: Gene List
S9: Gene List
S10: Gene List
S11: Gene List
S12: Gene List
S13: Gene List


Supplement Figure 2B: Expression plots of the seven genes being differentially expressed in all four investigated tissues during aging.
Gene Name Blood Expression Brain Expression Liver Expression Skin Expression
Gm8979
Igkv4-62
Lcn2
Rap2a
S100a6
S100a9
Vmp1

Supplement Figure 2C: Temporal expression profiles of the seven genes gm8979, igkv4-62, lcn2, rap2a, s100a6, s100a9
and vmp1, being differentially expressed in all four tissues during aging. The y-axis provide the expression strength as normalized
counts of expressed reads of each gene. Note that the positions of the figure legends indicate which boxplots belong to which
y-scale, for each gene respectively. With exception to lcn2 and s100a9 and gm8979, none of the genes show a consistent expression
pattern that is shared between the tissues.